Hertraz 150 is used to treat cancers that have high levels of a protein called epidermal growth factor receptor 2 (HER2) such as: early breast cancer, advanced breast cancer, advanced stomach cancer . Hertraz 150 is manufactured by Mylan Pharmaceuticals.
Ingredients of Hertraz 150
Trastuzumab 150mg.
Dosage forms
Powder for injection.
Uses – Indications of Hertraz 150
The specific treatment for HER2 metastatic breast cancer (BMC) is:
Combination drug with paclitaxel for the treatment of chemotherapy-naive patients.
Combination aromatase for the treatment of postmenopausal patients previously treated with trastuzumab.
Combination drug with docetaxel for the treatment of chemotherapy-naive patients.
Use in the treatment of early breast cancer:
For use in adult patients with HER2-positive early breast cancer.
Use after surgery or after dose chemotherapy (neo-adjuvant or adjuvant) and radiation therapy (if any).
Use for patients after chemotherapy with doxorubicin and cyclophosphamide.
Combination of drugs with adjuvant chemotherapy such as docetaxel and carboplatin.
Use in the treatment of metastatic gastric cancer:
It is indicated in combination with intravenous capecitabine or 5-fluorouracil and cisplatin for the treatment of HER2-positive metastatic gastric or esophageal junction cancer that has not previously received anticancer therapy. cancer for metastatic cancer.
Usage - Dosage Hertraz 150
How to use:
The drug is given by slow intravenous (intravenous, IV) infusion.
For a slow infusion of the initial dose over 90 minutes, if well tolerated, the next dose should be infused over 30 minutes.
Note: Absolutely do not inject or fast intravenous infusion because it can cause drug shock, dangerous to the patient's life.
Dosage: The dose of the drug used depends on the height, weight, health status and severity of the disease, absorption level, etc., which the doctor will decide on a different dosage level. Patient dosage can refer to the following:
Recommended initial dose within 1 week: The dose used is 4mg/kg/week infused over 90 minutes, the next dose will be 2mg/kg/week infused over 30 minutes if tolerability is good.
Dosage used once every 3 weeks: The starting dose is 8mg/kg/3 weeks infused over 90 minutes, 3 weeks after the dose is 6mg/kg, then repeat every 3 weeks as an infusion of 6mg/kg/time , the infusion time is 30 minutes for subsequent times if the patient's tolerability is good.
Contraindications of the drug Hertraz 150
The drug is not used for people who are sensitive to any ingredient of the drug, sensitive to murine protein or to any of the excipients.
Do not use the drug in patients with severe dyspnea at rest due to advanced malignancy or requiring supplemental oxygen therapy.
Side effects of Hertraz 150
Common side effects (10%):
There is a risk of infection, allergies, joint or muscle pain.
Bruising and bleeding, heart problems, fatigue, mouth ulcers.
Have diarrhea or constipation, skin and nail problems.
Hot flashes or sweating, changes in taste, abdominal pain.
Soreness, redness, and peeling in hands and feet.
Changes in blood pressure, trouble sleeping, lung problems, runny nose.
Have eye problems, headaches and dizziness.
Hands and feet swollen, loss of appetite.
Feeling or being sick, flu-like symptoms.
Common side effects (1%):
Anxiety or depression, dry mouth.
Change the way the kidneys work.
Infections such as chest or urine infections.
Numbness or tingling in fingers and toes.
Liver problems are very mild and are unlikely to cause symptoms.
Rare side effects (1%):
Jaundice and whites of the eyes.
Pneumonia.
Precautions/notes when using Hertraz 150
Tell your doctor if you experience any of the following symptoms:
Shortness of breath or chest pain, swelling of facial features, hives (may be allergic).
Nausea (impaired ability to eat and drink and not reduce prescribed medication).
Vomiting (vomiting more than 4-5 times in 24 hours).
Diarrhea (4 - 6 episodes in a 24-hour period).
Swollen feet or ankles. Sudden weight gain.
Signs of infection such as redness or swelling, pain when swallowing, coughing up mucus, or painful urination.
Pain that is not relieved by prescription medication.
Avoid driving while on medication.
Some self-care tips when using Herceptin 150mg for patients:
Drink at least 2-3 liters of water a day.
When nausea occurs, use anti-nausea medication as prescribed and eat small frequent meals. Sucking on lozenges and gum can also help when the patient is nauseous.
For flu-like symptoms, keep warm with blankets and drink plenty of water.
Acetaminophen or ibuprofen can help relieve discomfort caused by fever, headache, or body aches. But before using it, you should consult your doctor.
Do not consume alcoholic beverages during treatment.
Use of drugs for pregnant and lactating women
Women of childbearing potential: Contraception should be used during treatment with the drug and for 7 months after stopping the drug.
Pregnant women: Avoid using the drug because it can affect your health